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Daniel Lauer, MPH

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Daniel Lauer, MPH
Consultant

Daniel Lauer, MPH

Consultant (720) 465-3346 Boulder, CO dlauer@integral-corp.com

Mr. Daniel Lauer is an epidemiologist with 6 years of experience in epidemiology, environmental health, and risk assessment. Mr. Lauer has significant experience in the application and development of epidemiologic methods for understanding human health risks from environmental, occupational, and consumer product exposures. He has conducted systematic review, weight-of-evidence, and risk-of-bias assessments for a variety of biological and chemical exposures and outcomes. His specific areas of interest include cancer epidemiology, microbial risk assessments, critical reviews and syntheses of the published literature, and development of methods for evidence integration, including epidemiology, toxicology, and exposure science.

Occupational and Environmental Exposures

Systematic Review and Risk-of-Bias Analysis Performed systematic reviews of epidemiological and related scientific literature, including risk of bias analyses, for various occupational and environmental exposures including talc, formaldehyde, benzene, and methyl tert-butyl ether (MTBE).
Published Systematic Review and Study Quality Assessment Addressing Exposure to Talc and Risk of Various Cancers Served as second author on two published systematic reviews of the epidemiological, mechanistic, and toxicological evidence regarding the association between inhalation exposure to talc and risk of respiratory tract cancers, and perineal exposure to talc and risk of female reproductive cancers. Developed and implemented a rigorous study quality assessment using a hybrid method incorporating aspects of the frameworks developed for the EPA Integrated Risk Information System program and TSCA existing chemical programs, and by the Institute of Medicine and the National Toxicology Program Office of Health Assessment and Translation.
Meta-Analysis Performed a meta-analysis of occupational exposure to asbestos and the risk of laryngeal and pharyngeal cancer by fiber type.

Litigation Support

Cosmetic Talc Epidemiology Served as project manager and technical expert within the context of litigation cases in which it was alleged that exposure to trace levels of asbestos in cosmetic talcum powder products was associated with or contributed to causing pleural mesothelioma, peritoneal mesothelioma, and ovarian cancers.
PFAS Epidemiology In the context of various toxic tort cases, conducted comprehensive reviews and syntheses of the available epidemiological literature of the potential associations between long- and short-chain per- and polyfluoroalkyl substances (PFAS) and numerous human health endpoints, including cancer, immunotoxicity, neurological impairment, and thyroid disease.
MTBE Community Exposure Critically evaluated epidemiological evidence regarding the alleged association between exposure to MTBE stemming from an accidental ship spill and a wide variety of acute health effects.

Regulatory Support

TSCA Risk Evaluations Critical review of epidemiological evidence addressing various chemical exposures and cancer risks in support of TSCA risk evaluations.
Epidemiologic Evidence Triangulation Developed and published a novel framework for epidemiological evidence triangulation incorporating study quality and risk-of-bias approaches with a focus on identifying and quantifying potential sources of bias. Applied triangulation methods to an example evaluating occupational formaldehyde exposure and risk of myeloid leukemias and myeloid leukemia subtypes.

Microbial Risk Assessments

Oral Nicotine Products Performed risk assessment for exposure to microorganisms (including bacteria and fungi, endotoxins, beta-glucans, and mycotoxins) through inhalation and ingestion pathways. Compared measured levels of microbes in consumer products to health-based guidance values.

Lauer, D.J., A.J. Russell, H.N. Lynch, W.J. Thompson, K.A. Mundt, and H. Checkoway. 2024. Triangulation of epidemiologic evidence and risk of bias evaluation: A proposed framework and applied example using formaldehyde exposure and risk of myeloid leukemias. Global Epidemiology. 100143. doi.org/10.1016/j.gloepi.2024.100143.

Lynch, H.N., D.J. Lauer, W.J. Thompson, O. Leleck, R.D. Freid, J. Collins, K. Chen, A.M. Ierardi, A.M. Urban, P. Boffetta, and K.A. Mundt. 2023. Systematic review of the association between talc and female reproductive tract cancers. Front. Toxicol. 5:1157761.

Lynch, H.N., D.J. Lauer, W.J. Thompson, O. Leleck, R.D. Freid, J. Collins, K. Chen, A.M. Ierardi, A.M. Urban, M.A. Cappello, P. Boffetta, and K.A. Mundt. 2022. Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc. Front. Pub. Health 10:989111.

Cappello, M.A., A.M. Hernandez, D.J. Lauer, A.J. Russell, R.K. Brewster, L. Best, R. Fried, C. Boles, and J. Parker. 2022. Risk mitigation and disease control challenges of SARS-CoV-2 multidirectional transmission at ski resorts. Journal of Public Health and Emergency 6. doi: 10.21037/jphe-21-112.

Boles, C., R. Zisook, A.N. Buerger, C. Hamaji, C. Mathis, D. Lauer, R.K. Brewster, K.K. Meachum, M. Nonnenmann, and K.M. Unice. 2022. Semi-quantitative microbial risk assessment: A narrative review and proposed framework for health and safety practitioners. Journal of Public Health and Emergency 6. doi: 10.21037/jphe-22-1.

Lauer, D.J., K.A. Mundt, W.J. Thompson, and E.A. Best. 2020. Letter to the Editor: Largely unchanged annual incidence and overall survival of pleural mesothelioma in the USA. World J. Surg. 44(12):4279–4280. doi: 10.1007/s00268-020-05737-2.

Lauer, D., L.A. Wood, D. Steigerwald, L.P. Marshall, K. Keeton, L. Dobyns, B. Finley, and S.M. Benson. 2024. Asbestos and laryngeal cancer, a meta-analysis stratified by fiber-type. Poster presentation P519 at the Society of Toxicology Annual Meeting & ToxExpo. Salt Lake City, UT. March 11–14.

Russel, A.J., D. Lauer, W.J. Thompson, and K.A. Mundt. 2022. Triangulation of evidence based on a formal causal model: An example using a directed acyclic graph (DAG) in assessing benzene as a potential cause of chronic lymphocytic leukemia (CLL). Poster presented at the National Academies Workshop to Support EPA’s Development of Human Health Assessments: Triangulation of Evidence in Environmental Epidemiology. May 9. https://www.nationalacademies.org/event/05-09-2022/docs/DBF0DDB30EAC9424364D601644FA9C82A61341DFBFCB.

Fried, R.D., H. Lynch, W.J. Thompson, D. Lauer, O. Leleck, and K.A. Mundt. 2022. Quality-based systematic review of the epidemiological evidence on talcum powder use and risk of ovarian cancer. Poster presentation P608 at the Society of Toxicology Annual Meeting & ToxExpo. San Diego, CA. March 27-31. Toxicologist 186(S1):277. Abstract 3929.

Parker, J., R. Brewster, D. Lauer, C. Boles, A. Madl, and A. Jones. 2021. Microorganisms and associated toxins in cigarettes, ENDS, and other tobacco-related products: Current state-of-the-science and applications for microbial risk assessment. 74th Tobacco Science Research Conference. Boston, MA. August 29–31.

Lauer, D., J. Dent, K.A. Mundt, W.J. Thompson, and E. Best. 2020. Challenges of epidemiological assessments of point source carcinogen exposures and community health. Virtual poster presentation at the Society for Risk Analysis Annual Meeting. December 14.

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