we get to the real problem. with the insight to solve it.
DISCOVER HOWwe get to the real problem. with the insight to solve it.
DISCOVER HOWWe provide science and engineering insight, strategy, and project delivery for health, environmental, and natural resource challenges — past and present.
The services you need to get the right job done right
From analysis and assessment to negotiation and design, we have the services — and the team — to deliver the best solutions each and every time.
How? Our team of toxicologists, engineers, geoscientists, marine scientists, chemists, data scientists, and others skillfully blend technical expertise with big-picture context and insight.
The services you need to get the right job done right
From analysis and assessment to negotiation and design, we have the services — and the team — to deliver the best solutions each and every time.
How? Our team of toxicologists, engineers, geoscientists, marine scientists, chemists, data scientists, and others skillfully blend technical expertise with big-picture context and insight.
RECENT NEWS & ARTICLES
Remote Technologies to Address Today’s Challenges
Continue remediation system operations while keeping your employees safe during emergencies. Remote monitoring and control systems eliminate the need for staff to be onsite and can keep remediation systems operational in both emergency and routine operational...
read morePaul DeLeo and Anthony Luz Share New Safety Assessment of Quaternary Ammonium Compounds
Quaternary ammonium compounds, known as Quats, are a large class of chemicals used in consumer and industrial products for their antimicrobial properties. Quats are the active ingredient in many disinfectant products and are among the most extensively used. Integral...
Acoustics: Integral Scientists Coauthor Article in Journal of Marine Science and Engineering
Understanding the effects of underwater sound on marine life is critical for offshore and marine renewable energy (MRE) projects. Kaustubha Raghukumar, Ph.D., of Integral Consulting, is the lead author of “A Vector Sensor-Based Acoustic Characterization System for...
A Message to Our Valued Clients and Business Partners on Integral’s Response to COVID-19
As all of us ply the uncharted waters of the unfolding COVID-19 situation, we want you to know that Integral’s operations are fully up and running. Every day, we are making the necessary adaptations to ensure that our personnel and services will continue to be available to you.
CASE STUDY
Development of Regulatory Toxicity Criteria for Lindane and Isomers
OUR CHALLENGE
Although lindane is no longer produced or used agriculturally in the United States, exposure to hexachlorocyclohexane (HCH) isomers is of continuing concern due to past usage and persistence in the environment. The risk-based standards that were being applied for these compounds at our client’s site were derived using outdated toxicity criteria—namely these criteria did not consider the full set of toxicological data currently available for the compounds.
OUR APPROACH
Our team performed a technical review of the toxicological literature for the HCH compounds and determined the most sensitive target endpoint, potential carcinogenicity, and mode of action by which each isomer elicits toxicity. Our findings supported the derivation of threshold-based criteria, rather than those that assume linearity at low doses. We performed dose-response evaluations to derive toxicity criteria.
OUR IMPACT
Our recommended toxicity criteria were peer-reviewed and accepted by the Nevada State regulatory agency for use. Our state-of-the-science technical evaluation resulted in a significantly better understanding of the risks posed by these chemicals, and lead to the development of alternative risk-based standards.
