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Morgan Willming, Ph.D., DABT

Morgan Willming, Ph.D., DABT
Consultant

Morgan Willming, Ph.D., DABT

Consultant

Dr. Morgan Willming is a toxicologist with diverse experience in environmental and human health risk assessment, per- and polyfluoroalkyl substance (PFAS) regulatory toxicology, consumer product safety assessment, toxicity analysis and prediction, and risk communication. She has helped clients in the consumer products industry, chemical trade associations, pharmaceutical industry, and the legal sector interpret toxicological data and evaluate regulatory requirements of FDA, EPA, and international regulatory authorities. She brings strategic problem solving and technical communication skills to address challenges related to toxicology and risk assessment. Her experience in developing multi...

Dr. Morgan Willming is a toxicologist with diverse experience in environmental and human health risk assessment, per- and polyfluoroalkyl substance (PFAS) regulatory toxicology, consumer product safety assessment, toxicity analysis and prediction, and risk communication. She has helped clients in the consumer products industry, chemical trade associations, pharmaceutical industry, and the legal sector interpret toxicological data and evaluate regulatory requirements of FDA, EPA, and international regulatory authorities. She brings strategic problem solving and technical communication skills to address challenges related to toxicology and risk assessment. Her experience in developing multisector partnerships has facilitated improved stakeholder coordination to address emerging chemical risks.

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Product Safety: Annaleise Conway Presents on Sunscreen Testing at PCPC Symposium

Press Release

October 25 2021

PFAS

Regulatory Toxicology Evaluations for PFAS, Worldwide Critically examined the scientific basis of proposed PFAS rulemakings at the state, federal, and international levels, and assessed the extent to which they are founded on sound scientific principles. Prepared written technical comments evaluating the underlying toxicological assessments for proposed drinking water maximum contaminant levels, human health guidelines, aquatic life criteria, and hazardous substance designations for PFAS compounds.
PFAS Regulatory Tracking, U.S. Maintains awareness of emerging regulations for PFAS in drinking water, groundwater, soils, and consumer products throughout the United States. Contributes updates to support Integral’s PFAS Regulatory Map.
Integral’s Monthly PFAS Alerts, U.S. Participates in updating continuous literature reviews and summarizing scientific publications regarding PFAS occurrences, fate and transport, remediation and treatment, and toxicology, as well as environmental and human safety.
PFAS Stakeholder Coordination and Risk Communication, Idaho Communicated PFAS toxicology and health risks to stakeholders via presentations and outreach materials for public drinking water system operators, state regulatory agencies, local public health officials, and the general public. Developed statewide PFAS risk communication plans and supported interagency PFAS response to address PFAS in drinking water.

Product Stewardship

Safety Data for Sunscreen Active Ingredients, U.S. Supports the clinical safety assessment of sunscreen active ingredients for the Personal Care Products Council to meet FDA regulatory requirements for the safety of ultraviolet filters.  Provides toxicological support and study coordination for in vitro permeation testing, in vitro metabolism, and clinical trials to be conducted according to FDA guidance.  Conducted a written literature review integrating in silico predictions of ultraviolet filter metabolites expected in humans and rodents to identify and evaluate the toxicity of potential metabolites.
Safety Assessment of Personal Care Product Ingredients, U.S. Provided critical evaluation of toxicity data and reports generated to support safety for more than 100 personal care product ingredients. Reviewed toxicity data for each ingredient compiled from publicly available databases, including the European Chemicals Agency, European Food Safety Administration, FDA, and Cosmetic Ingredient Review. Applied product-specific exposure assumptions according to industry standards to determine safety for each ingredient.
Improving the Sustainability Profile of a Portfolio of Consumer Product Ingredients, U.S. Screened a library of ingredients based on chemical properties, biodegradability, and aquatic toxicity using publicly available chemical and toxicity databases to determine environmental risk profiles for each ingredient. Grouped ingredients according to chemical structure and determined surrogates appropriate for read-across.

Pharmaceutical Risk and Toxicology

Environmental Risk Assessment of a Novel Pharmaceutical, U.S. Assessed the aquatic environmental risk of a pharmaceutical with a novel mode of action for its new drug application for the FDA.  Provided a weight-of-evidence assessment based on read-across compounds, mode of action analysis, adverse outcome pathways, and clinical and nonclinical safety data. Calculated expected environmental concentrations considering in silico phototransformation predictions, biodegradation, and effluent and stream modeling.
Environmental Risk Assessment of an Oral Care Active Ingredient, Switzerland Evaluated the aquatic environmental risk of a new product indication for an oral care ingredient in support of a regulatory submission for Swissmedic. Derived predicted no effect levels and predicted environmental concentrations based on published literature and expected frequency of usage in Switzerland.
Toxicity and Regulatory Assessment of Hexavalent Chromium, U.S. Provided a review of the carcinogenic mode of action for hexavalent chromium in humans and evaluated the implications for a trade association of proposed human health guidelines and regulatory levels in drinking water at the state and national level.

Human Health Risk Assessment

Petroleum Vapor Intrusion at a Child Care Facility, Southwest Idaho Conducted a human health risk assessment for petroleum vapor chemicals from an underground storage tank release that was impacting a child care facility. Evaluated indoor air sampling data and assessed human health risks for children and facility workers. Provided a health risk assessment report and recommendations for preventing and reducing exposures.
Assessment of Metals in Fish and Derivation of Consumption Advisories, Coeur d’Alene, Idaho Assessed health risks of metals in fish tissue (mercury, arsenic, cadmium, lead) associated with contamination from a mining Superfund site. Derived fish consumption advisory guidance for populations of concern and generated technical reports and stakeholder presentations.
Metals in Soils at a Former Mining Site, Idaho Evaluated lead and other metals in soil and dust at a historical mining townsite to assess human health risks for recreational site users and residents. Determined human exposure pathways and assessed acute and chronic exposures. Evaluated lead exposures using the EPA Integrated Exposure Uptake Biokinetic and Adult Lead models.
Response to Residential Elemental Mercury Release, Boise, Idaho— Evaluated mercury vapor clearance data after exposure of residents to acutely toxic levels of mercury vapors. Coordinated with EPA On-Scene Coordinators to ensure cleanup was conducted appropriately and evaluated indoor vapor clearance data to ensure no additional exposures. Generated a health consultation report and health-based recommendations for impacted site residents.

Ecological Risk Assessment

Toxicity Prediction and Extrapolation Modeling, EPA, Office of Research and Development Supported development of acute toxicity extrapolation tools to improve cross-species toxicity prediction of aquatic threatened and endangered species. Analyzed and curated acute toxicity data sets derived from EPA’s ECOTOX database for use in developing models using R statistical software. Communicated results in peer-reviewed publications, conferences, and online tool platform.
Aquatic Ecotoxicity of Pesticides, Antimicrobial Compounds, and Temperature Regimes, Lubbock, Texas Designed and performed acute and chronic toxicity tests using insecticides, fungicides, and antimicrobial compounds on aquatic invertebrates (daphnids, chironomids, amphipods), and larval amphibians in aqueous and sediment assays. Assessed toxicity of compounds under realistic daily temperature regimes. Completed statistical analyses and interpreted data to assess chemical mixture effects and generate dose–response relationships for ecotoxicological endpoints.

Litigation Support

Exposure Assessment Regarding PCBs, U.S. Assisting with data analysis regarding potential exposure to PCBs via inhalation of indoor air. Conducted literature reviews and technical summaries of emerging literature on relevant chemical exposure pathways. Supports preparation of expert reports.
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