Toxicology: Research on PFAS and Safety of SARS-CoV-2 Disinfectants Now Available
April 28, 2020

Integral posters present research on PFAS and on safety evaluations.

Scientific posters prepared for the 2020 Society of Toxicology’s (SOT) Annual Meeting, which was canceled last month, are now available on the SOT website.

Integral scientists Anthony Luz, Ph.D., and Paul DeLeo, Ph.D., describe new research in a poster titled “Interspecies Extrapolation of Toxicity Data for Perfluorohexanoic Acid (PFHxA).” Their research shows that the differences in toxicokinetics for PFHxA across mammalian species are not large, and that EPA’s default approach of body-weight scaling to the ¾ power is an appropriate method for extrapolating between species.

In addition, safety assessment information on disinfectants used for SARS-CoV-2, the virus that causes COVID-19, is also presented in “Human Health Hazard Assessments of Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC) and Didecyl Dimethyl Ammonium Chloride (DDAC).” The hazard assessments found that compounds ADBAC and DDAC are not systemically toxic, carcinogenic, or developmental or reproductive toxicants. The main concern associated with exposure is local effects through irritation.

For more information, contact Dr. Luz at aluz@integral-corp.com or Dr. DeLeo at pdeleo@integral-corp.com.