Current approaches used to set drinking water standards for perfluoroalkyl substances (PFAS) are increasingly relying on blood measurements in animals and assumptions about human kinetics. Presentations by Integral Consulting Inc. (Integral) toxicologists Philip Goodrum, Ph.D., DABT, and Janet Anderson, Ph.D., DABT, at the upcoming Society of Toxicology (SOT) Annual Meeting and ToxExpo on March 11–15, will focus on how uncertainties in the underlying blood serum data and PFAS kinetic information have implications for risk assessment and communication. The 2018 conference, held in San Antonio, Texas, will cover advances in toxicology from the past year. Integral will present on PFAS in an all-day poster session on Tuesday, March 13. Integral Principal Paul DeLeo, Ph.D., who leads Integral’s business practice in product stewardship, will also attend the conference.
The dynamic nature of the available science on emerging contaminants presents a fundamental challenge for risk managers and communicators. Integral’s toxicologists have extensive experience in quantifying uncertainties and presenting information in a manner that informs decision making. Another example of our work in this area will be presented in a poster coauthored by Dr. Goodrum and presented at an all-day session on Wednesday, March 14. This poster discusses a reassessment of co-critical studies used to support the reference dose for 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Tuesday, March 13, Poster Sessions
Poster (P782) presentation: “Application of Internal Dosimetry for Perfluoroalkyl Acids and Methods to Assess Uncertainty Factors Used in Risk Assessment”
Authors: P. Goodrum and J. Anderson
Poster (P784) presentation: “What Does That Blood Level Mean? The Assumptions Underlying Interpretations of Health Effects from Internal Doses”
Authors: J. Anderson, P. Goodrum, and S. Hays
Wednesday, March 14, Poster Session
Poster (P413) presentation: “Application of Quantitative Approaches to Assess Uncertainties in the Development of Toxicity Values: A Case Study Involving the Reference Dose (RfD) for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)”
Authors: D. Wikoff, P. Goodrum, L. Haws, and R. Budinsky